Breast Cancer Treatment With Precision Medicine

The breast cancer is a kind of a tumor which arises from the cells of the breast. This can affect both the men and the women alike, however, it is more common in women than men. It is believed that the breast cancer in men is rare but the outcome is worse compared to breast cancer in women. It is mostly because the diagnosis of cancer in men is often late and cancer has already spread beyond the point of recovery. The symptoms are similar in both men and women and the most common are lump or change in the skin of the breast and nipple discharge. Cancer can happen at any age but in men, it usually occurs after the age of 60 years.

The researchers have found a way to make the cancer cells susceptible to treatment. The team also found out that the protein RYBP usually prevents the DNA repair in the cancer cells. The protein RYBP makes the cancer cells more sensitive to DNA damage. The scientists believe that the chemo or radiation therapy will be more effective in such case. This discovery can also be another option for precision medicine and would give the doctor`s option to make changes to the treatment options as per the patient's DNA. The new treatment option with RYBP also gives the option to know beforehand whether the specific type of chemotherapy will work for the patient or not. Another opportunity that the scientists are looking at is to develop medicines which can treat cancer by simulating the RYBP protein in the tumors and it includes breast cancer as well.

The team found that the breast cancer cells with a high amount of RYBP are more sensitive to DNA damage post the radiation or drug treatment. This treatment also includes PARP inhibitors which are the enzyme poly ADP ribose polymerase and are used in cancer treatment. These factors make it easy for the high RYBP cancer cells in the breast to adapt in a better way to treat cancer by using the radiation and anticancer therapy. The RYBP is a member of the large epigenetic protein complex called PRC1. The protein is known to regulate the gene expression and in certain previous research, the team found that the PRC1 complex helps to repair the DNA damage caused to the cancer cells.

It was also found that the RYBP prevents the DNA repair. The team further worked on it to find the mechanism at the molecular level which is responsible for this occurrence. The team established that cancer cells which resist therapy are also able to repair the DNA damage themselves and if this is prevented the treatment of cancer would be more effective. The team is looking at ways to make this kind of treatment possible for all. They want to enable the doctors to be able to screen and diagnose their patients better and advise the best treatment to them with least amount of side effects.